Barcelona from 28 to 30 April 2014
Barcelona GPCR Spring Conference 2014


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Program

(Download the program in .pdf)

(Download the speakers' abstracts in .pdf)

(Download the posters abstracts in .pdf)


1st DAY, APRIL 28



08.30-09.15  Registration of participants

09.15-09.30  Welcome remarks

09.30-12:30  Session I.  Chairs: Nuska Tschammer and Slawomir Filipek

09.30-10.00 Michel Bouvier (University of Montreal, Canada): Exploring the molecular basis and pharmacological consequences of ligand-biased signaling at G protein-coupled receptors using biosensors

10.00-10.30 Klaus Mohr (University of Bonn, Germany): Beyond crystals: ligand-dependent versatility of GPCR-signalling

10.30-11.00 Thomas Frimurer (University of Copenhagen, Denmark): Mutational-guided Unbiased Modeling of 7TM Receptors -Making Virtual Screening for Novel Chemo-types a Reality

11.00-11.30 http://eventia.upf.edu/img/ico/coffee_break.gif Coffee Break

11.30-12.00 Marta Filizola (Icahn School of Medicine at Mount Sinai, New York, USA): Beyond standard molecular dynamics: investigating the molecular mechanisms of G protein-coupled receptors with enhanced molecular dynamics methods

12.00-12.30 Martin Lohse (University of Würzburg, Germany): Optical analysis of receptor signaling


12.30-13.00  Poster presentations, 8 x 3 min

13.00-16.00  Lunch and Poster session

14.00-16.00 Meeting of the management committee

15.00-16.00 GPCRDB Workshop: Demonstration of new data, tools and visualization and workshop (with own computer) and collection of user comments


16.00-19.15:  Session II. Chairs: Ago Rinken and Leonardo Pardo

16.00-16.30 Martha Sommer (Charité - Universitätsmedizin Berlin, Germany): The versatility of arrestin-receptor interactions

16.30-17.00 Peter McCormick (University of East Anglia, UK): G protein-coupled heteromers: bias and allostery all in one

17.00-17.30 Francisco Ciruela (University of Barcelona, Barcelona, Spain): Disease-mediated GPCR oligomer dynamics in the brain

17.30-18.00 http://eventia.upf.edu/img/ico/coffee_break.gif Coffee break

18.00-18.30 Maria Luz López (Universidad Complutense de Madrid): Expanding the potential of druggable GPCRs

18.30-19.00 Fiona Marshall (Heptares Therapeutics, UK): Structures based drug discovery applied across the GPCRome.

19.00-19.15 Martin Lohse (University of Würzburg, Germany): How to get funded in Europe


From 19.15 Evening activities

19:15 Sergi Verdejo (MOOVE BARCELONA): Instructions for the walking tour via Barcelona*.
          *The tour will end at the dinner venue Casa de la Seda

20:30 Dinner: Casa de la Seda (address: carrer Sant Pere Més Alt, 1 - Barcelona)

 

 

2nd DAY, APRIL 29



09.00-11.00 Session I: GPCR Lipid/Protein Interactions (chairs: Masha Niv and Jana Selent)

09:00-09:30 Anthony Watts (Oxford University, UK): Lipid dependence of GPCR function and oligomerization in defined bilayers - NTS1 as a case study

09:30-10:00 Kathleen Van Craenenbroeck (Ghent University, Belgium): Heterodimerization and cross-desensitization between dopamine D2-like receptors and µ opioid receptor.

10:00-10:30 Selected short talks

Ramon Guixà-González (IMIM-Universitat Pompeu Fabra, Spain): Membrane omega-3 fatty acids modulate oligomerization of G protein-coupled receptors

Philippe Rondard (Université Montpellier, France): Major ligand-induced rearrangement of the heptahelical domain interface in a G protein-coupled receptor dimer

10:30-11:00 Discussion

11.00-11.30 http://eventia.upf.edu/img/ico/coffee_break.gif Coffee break
 

11.30-13.30 Session II: Biased Signaling (chairs: David Gloriam and Henry Vischer)

11:30-12:00 Philippe De Deurwaerdère (University of Bordeaux, France): 5-HT2C receptors are involved in distributed controls in basal ganglia: impact of dopamine transmission on these controls

12:00-12:30 Selected short talks

Dorothee Möller (Friedrich Alexander University, Erlangen): Biased Ligands For Dopamine D2/D3 Receptors

Jeremy Shonberg (Monash University, Australia): A Structure–Activity Analysis Of Biased Agonism At The Dopamine D2 Receptor

12:30–13:00 Maria Waldhoer (Novo Nordisk): Real-time Trafficking & Signalling of the Glucagon-like Peptide-1 Receptor

13:00-13:30 Discussion
 

13.30-15.00 Lunch and Poster session
 

15.00-17.00 Session III: GPCR dynamics (chairs: Xavier Deupi and Jan Steyaert)

15:00-15:30 Sebastien Granier (Montpellier University, France): Structural pharmacology of opioid receptor

15:30-16:00: Guillaume Lebon (Montpellier University, France): Molecular determinant of agonist binding at the human adenosine A2A receptor

16:00-16:30 Selected short talks

Alina Tabor (University of Erlangen-Nuremberg): Imaging of dopamine receptor-ligand complexes by TIRF microscopy

Arnau Cordomí (Universitat Autònoma de Barcelona, Spain): Sulfur-Containing Amino Acids in 7TMRs: Molecular Gears for Pharmacology and Function

16:30-17:00 Discussion

17.00-17.30 http://eventia.upf.edu/img/ico/coffee_break.gif Coffee break
            

17.30-19.30 Session IV: Discovery & Design of GPCR Ligands (chairs: György Keseru and Esther Kellenberger)

17:30-18:15 Selected short talks

Albert J. Kooistra (VU University Amsterdam, the Netherlands): Fragment-based and structure-based chemogenomics studies of GPCR-ligand interactions

Trond V. Hansen (University of Oslo, Norway): A New Specialized Pro-resolving Mediator (SPM) with potent GPCR agonist effects

Xavier Gómez-Santacana (Institute for Bioengineering of Catalonia, Spain): A drug-like photoswitchable GPCR allosteric ligand with light-dependent  control of animal motility

18:15-18:45 Jordi Quintana (Parc Científic de Barcelona, Spain): Chemical biology for drug discovery: case studies in drug repurposing and in target finding

18:45-19:30 Discussion


19.30 Closing Remarks

 

3rd DAY, APRIL 30:  GPCRDB Satellite Meeting (Contributing Groups Only*)


09.00-10.30  Presentations from contributing groups (10-15 min. each)

10.30-12.00  Discussion of new data, tools and integration with external resources

12.00-13.00  Planning of STSMs, applications and new collaboration


*This is a planning meeting for groups contributing cross-linking, sharing data or programming. If you have a new contribution in mind please contact David Gloriam (david.gloriam@sund.ku.dk).